IR-825 CAS1558079-49-4 用于腫瘤光熱光動(dòng)力治療-僅科研

西安瑞禧生物科技有限公司可以提供一種用于腫瘤癌癥細(xì)胞的光熱治療和光動(dòng)力治療的近紅外熒光染料IR-825，該產(chǎn)品的吸收波長(zhǎng)是810nm,發(fā)射波長(zhǎng)是830nm,該產(chǎn)品的末端帶有羧基COOH活性基團(tuán)可以參與反應(yīng)連接其他分子，這個(gè)產(chǎn)品的造價(jià)要低于ICG-COOH，可以廣泛用于腫瘤的光熱治療。我公司制備的IR-825純度95.4%，可以溶解在二氯甲烷、甲醇、DMF、DMSO里。

特別說(shuō)明：該產(chǎn)品僅僅用于科學(xué)研究，不用于人體及藥物開(kāi)發(fā)

IR-825 from ruixibio is a near-infrared dye (NIR). IR-825, after encapsulated into nanoparticles may be useful for cancer photothermal and photodynamic therapy. IR-825 nanoparticles showed pH-dependent fluorescence emission and excellent near-infrared (NIR) irradiation of cancer cells targeted in vitro to provide cytotoxicity. IR-825 nanoparticles showed efficient tumor homing together with rapid renal excretion behaviors, as revealed by MR imaging and confirmed by biodistribution measurement. Notably, when irradiated with an 808 nm laser, tumors on mice with IR-825 nanoparticle injection are completely eliminated without recurrence within 60 days, demonstrating the high efficacy of photothermal therapy.

Certificate of Analysis

 

 

 

General properties:

 

Name：IR825

 

Molecular Weight：823.4 Dalton

 

Cat.#：R-H-6012

 

Lot.#： RM017172

 

Date of Analysis：2018.01.09

 

Recommended Retest date：2019.01.09

 

Stability： 12 months

 

Storage： -20°C in the dark

 

Structure

 

 

 

 

Items		Specification	Results
Appearance		solid	solid
1H NMR		Identical to the structure	Identical to the structure
Foreign Material		None	None
Purity by HPLC		＞95%	95.4%
Report Date: 2018.01.09

Attachment 1: HPLC

Attachment 2: MS