PEG制備方法7-醫(yī)用可生物降解PLGA-PEG-MAL的合成

這類(lèi)共聚物的應(yīng)用報(bào)道近年來(lái)越來(lái)越多。由于聚醚的存在, 使共聚物具有親水性和柔軟性,在藥物控制釋放中可作為表面活性劑, 微球表面修飾劑, 也可用于制備載藥微球, 載藥毫微球等。

目前研究得較多的為聚乙二醇2聚酯及聚乙二醇2聚氨基酸共聚物。聚乙二醇2聚酯共聚物一般用聚乙二醇與環(huán)狀內(nèi)酯開(kāi)環(huán)共聚制備以聚乙二醇2聚乳酸共聚物的制備示例如下[ 39 ] (式22) :

聚乙二醇2聚氨基酸共聚物一般用聚乙二醇胺與環(huán)狀氨基酸氮酸酐開(kāi)環(huán)共聚制備, 以聚乙二醇2聚芐酯谷氨酸共聚物的制備, 示例如下[ 40 ] (式23) :

產(chǎn)品列表：

PLGA-PEG-NH2,PLGA-PEG-Amine 

PLGA-PEG-COOH,PLGA-PEG-carboxyl

PLGA-PEG-MAL,PLGA-PEG-Maleimide

PLGA-PEG-NHS 

PLGA-PEG-N3,PLGA-PEG-azide

PLGA-PEG-Alkyne

PLGA-PEG-SH,PLGA-PEG-Thiol

PLGA-PEG-Biotin 

PLGA-PEG-CHO,PLGA-PEG-aldehyde

PLGA-PEG-OPSS

PLGA-PEG-OH/hydroxyl

PLGA-PEG-Hydrazide/ HZ

PLGA-PEG-Silane

PLGA-PEG-Acrylates (ACRL)

PLGA-PEG-Lipoic acid/LA

PLGA-PEG-Tosyl,PLGA-PEG-Tosylate

PLGA-PEG-Acetylthio

PLGA-PEG-Aminooxy

PLGA-PEG-Nitrophenyl Carbonates (NPC)

PLGA-PEG-SAS, SC, SCM, SG, SS, SVA

PLGA-PEG-Epoxides (EPOX)

PLGA-PEG-Valeric Acids (VA)

PLGA-PEG-Acrylamide

PLGA-PEG-Bromide(Br)

PLGA-PEG-Vinylsulfone(VS)

PLGA-PEG-Methacrylate (MA)

PLGA-PEG-Iodoacetate(IA)

PLGA-PEG-Chloride

PLGA-PEG-DBCO

PLGA-PEG-TCO

PLGA-PEG-TZ,PLGA-PEG-Tetrazine

PLGA-PEG-Folate ，PLGA-PEG-FA/folic acid 

PLGA-PEG-Multi-Arms (4 arm 8arm)

PLGA-PEG-Protected Amines (FMOC, tBOC)

PLGA-PEG-CHEMS

PCL-PEG-NH2,PCL-PEG-Amine 

PCL-PEG-COOH,PCL-PEG-carboxyl

PCL-PEG-MAL,PCL-PEG-Maleimide

PCL-PEG-NHS 

PCL-PEG-N3 PCL-PEG-azide

PCL-PEG-Alkyne

PCL-PEG-SH ,PCL-PEG-Thiol

PCL-PEG-Biotin 

PCL-PEG-CHO, PCL-PEG-aldehyde

PCL-PEG-OPSS

PCL-PEG-OH /hydroxyl

PCL-PEG-Hydrazide, PCL-PEG-HZ

PCL-PEG-Silane

PCL-PEG-Acrylates (ACRL)

PCL-PEG-Lipoic acid LA

PCL-PEG-Tosyl,Tosylate

PCL-PEG-Acetylthio

PCL-PEG-Aminooxy

PCL-PEG-Nitrophenyl Carbonates (NPC)

PCL-PEG-SAS, SC, SCM, SG, SS, SVA

PCL-PEG-Epoxides (EPOX)

PCL-PEG-Valeric Acids (VA)

PCL-PEG-Acrylamide

PCL-PEG-Bromide(Br)

PCL-PEG-Vinylsulfone(VS)

PCL-PEG-Methacrylate (MA)

PCL-PEG-Iodoacetate(IA)

PCL-PEG-Chloride

PCL-PEG-DBCO

PCL-PEG-TCO

PCL-PEG-TZ/Tetrazine

PCL-PEG-Folate ，FA， folic acid 

PCL-PEG-Multi-Arms (4 arm 8arm)

PCL-PEG-Protected Amines (FMOC, tBOC)

PCL-PEG-CHEMS

PLA-PEG-NH2,PLA-PEG-Amine 

PLA-PEG-COOH,PLA-PEG-carboxyl

PLA-PEG-MAL,PLA-PEG-Maleimide

PLA-PEG-NHS 

PLA-PEG-N3 PLA-PEG-azide

PLA-PEG-Alkyne

PLA-PEG-SH ,PLA -PEG-Thiol

PLA-PEG-Biotin 

PLA-PEG-CHO, PLA -PEG-aldehyde

PLA-PEG-OPSS

PLA-PEG-OH /hydroxyl

PLA-PEG-Hydrazide, PLA -PEG-HZ

PLA-PEG-Silane

PLA-PEG-Acrylates (ACRL)

PLA-PEG-Lipoic acid LA

PLA-PEG-Tosyl,Tosylate

PLA-PEG-Acetylthio

PLA-PEG-Aminooxy

PLA-PEG-Nitrophenyl Carbonates (NPC)

PLA-PEG-SAS, SC, SCM, SG, SS, SVA

PLA-PEG-Epoxides (EPOX)

PLA-PEG-Valeric Acids (VA)

PLA-PEG-Acrylamide

PLA-PEG-Bromide(Br)

PLA-PEG-Vinylsulfone(VS)

PLA-PEG-Methacrylate (MA)

PLA-PEG-Iodoacetate(IA)

PLA-PEG-Chloride

PLA-PEG-DBCO

PLA-PEG-TCO

PLA-PEG-TZ,PLA-PEG-Tetrazine

PLA-PEG-Folate，PLA-PEG-FA， folic acid 

PLA-PEG-Multi-Arms (4 arm 8arm)

PLA-PEG-Protected Amines (FMOC, tBOC)

PLA-PEG-CHEMS

PAA-PEG-NH2,PAA-PEG-Amine 

PAA-PEG-COOH,PAA-PEG-carboxyl

PAA-PEG-MAL,PAA-PEG-Maleimide

PAA-PEG-NHS 

PAA-PEG-N3 PAA-PEG-azide

PAA-PEG-Alkyne

PAA-PEG-SH ,PAA-PEG-Thiol

PAA-PEG-Biotin 

PAA-PEG-CHO, PAA-PEG-aldehyde

PAA-PEG-OPSS

PAA-PEG-OH /hydroxyl

PAA-PEG-Hydrazide, PAA-PEG-HZ

PAA-PEG-Silane

PAA-PEG-Acrylates (ACRL)

PAA-PEG-Lipoic acid LA

PAA-PEG-Tosyl,Tosylate

PAA-PEG-Acetylthio

PAA-PEG-Aminooxy

PAA-PEG-Nitrophenyl Carbonates (NPC)

PAA-PEG-SAS, SC, SCM, SG, SS, SVA

PAA-PEG-Epoxides (EPOX)

PAA-PEG-Valeric Acids (VA)

PAA-PEG-Acrylamide

PAA-PEG-Bromide(Br)

PAA-PEG-Vinylsulfone(VS)

PAA-PEG-Methacrylate (MA)

PAA-PEG-Iodoacetate(IA)

PAA-PEG-Chloride

PAA-PEG-DBCO

PAA-PEG-TCO

PAA-PEG-TZ/Tetrazine

PAA-PEG-Folate ，PAA-PEG-FA， folic acid 

PAA-PEG-Multi-Arms (4 arm 8arm)

PAA-PEG-Protected Amines (FMOC, tBOC)

PAA-PEG-CHEMS