抗體藥物偶聯(lián)物 (ADC) 是一種蛋白質(zhì)—通常為單克隆抗體 (mAb)——通過ADC交聯(lián)劑共價結(jié)合（偶聯(lián)）到小分子藥物。 mAb的定位能力與強(qiáng)效抗癌藥物相結(jié)合，可敏感地辨析健康細(xì)胞和患病細(xì)胞。 鑒于偶聯(lián)藥物的效力，開發(fā)這些生物治療藥物比單獨(dú)開發(fā)mAb更加困難，包括設(shè)計用于詳細(xì)表征ADC的 UHPLC系統(tǒng)、質(zhì)譜系統(tǒng)和LC色譜柱，能讓您更方便地分離和表征這些新型分子。

ADC藥物的藥效和清除率都與藥物抗體偶聯(lián)比（DAR）值有關(guān)，因此在藥物開發(fā)過程中必須對其精確分析。尺寸排阻色譜法和疏水色譜法是在天然生理條件下檢測DAR的兩種最常用的方法。

相關(guān)資料：

Mouse Anti-vc-PAB-MMAE mAb (B11F11)

Rabbit Anti-MMAF pAb

Mouse Anti-MMAF mAb (F3B11)

Mouse Anti-MMAE / F mAb (B12A2)

Mouse Anti-MMAE /F mAb (C12A1)

Rabbit Anti-DM1/4 pAb

Mouse Anti-DM1/4 mAb (F1D5)

Mouse Anti-DM1/4 mAb (G2F3)

Rabbit Anti-Calicheamicin pAb

Mouse Anti-Calicheamicin mAb (B1G9)

Mouse Anti-Calicheamicin mAb (C1F12)

Rabbit Anti-Duocarmycin pAb 

Mouse Anti-Duocarmycin mAb (E11A1)

Mouse Anti-Duocarmycin mAb (H7A9)

Mouse Anti-Duocarmycin mAb (E6B3) 

Rabbit Anti-PNU-159682 pAb

Mouse Anti-PNU-159682 mAb (F7F2)

Mouse Anti-PNU-159682 mAb (C1E3)

Mouse Anti-PNU-159682 mAb (D12H11)

Rabbit Anti-Amanitin pAb

Mouse Anti-Amanitin mAb (H3E1)

Mouse Anti-Amanitin mAb (H12D6)

Mouse Anti-Amanitin mAb (C2C4)

Rabbit Anti-SN38 pAb

Mouse Anti-SN38 mAb (10F11A9D6)

Mouse Anti-SN38 mAb (8E10F12F3)

Mouse Anti-SN38 mAb (8E10A4A1)

Rabbit Anti-PBD SG3199 pAb

Mouse Anti-PBD SG3199 (7H6H9A6) mAb

Mouse Anti-PBD SG3199 (8G2H12A9) mAb

Mouse Anti-PBD SG3199 (8B3D12G1) mAb

Dolastatin 10 Cas號：110417-88-4  微管蛋白聚合抑制劑

Monomethyl Dolastatin 10 Cas號：203849-91-6單甲基澳瑞他汀

Auristatin E Cas號：160800-57-7  澳瑞他汀

Monomethyl Auristatin E  474645-27-7微管相關(guān)抑制劑

Auristatin F Cas號：163768-50-1 澳瑞他汀

Monomethyl Auristatin F  Cas號：745017-94-1

HTI-286 228266-40-8

Tubulysin M 205304-86-5

Maytansinoid AP-3  66547-09-9

Maytansinol 57103-68-1

DM1 139504-50-0

DM4 799840-96-3

Boc-Val-Dil-Dap-OH

Boc-Val-Dil-Dap-Phe-OMe

Boc-Val-Dil-Dap-Doe

Boc-Val-Dil-Dap-Nrp

Boc-N-Me-Val-Val-Dil-Dap-OH

Tubulysin IM-1

Tubulysin IM-2

Tubulysin IM-3

Duocarmycin SA  152785-82-5

Duocarmycin TM

Duocarmycin MA

Duocarmycin DM

Nemorubicin 108852-90-0

PNU-159682 202350-68-3

Calicheamicin g1 108212-75-5

Acetyl-Calicheamicin g1 108212-76-6

a-Amanitin 23109-05-9

PBD-dimer 1222490-34-7